Teams will be given "temporary dispensation" to make five substitutions to help with the congested schedule they could face when the season resumes, FIFA has proposed.
Most leagues around the world have been halted by the coronavirus pandemic.
The dispensation can be implemented by organizers for competitions scheduled until the end of the 2021 season.
A FIFA spokesman told BBC Sport "health comes first" and no competition is "worth risking a single human life".
They added: "Football should only resume when the health authorities and governments say it is absolutely safe and non-disruptive of health services being delivered to the populations.
"Safety of the players is one of FIFA's main priorities. One concern in this regard is that the higher-than-normal frequency of matches may increase the risk of potential injuries due to a resulting player overload."
The proposal will need to be approved by the International Football Association Board (IFAB), football's rule-making body, and whether it is implemented is at the "discretion of the relevant competition organizer".
BBC Sport understands IFAB will respond positively because this was already being discussed as an important way to assist player welfare.
How it will work
In competitions where less than five substitutions are currently allowed, teams can now use up to five substitutions during the match.
The five substitutions would be allowable within a maximum of three slots, as well as during half-time.
The possibility of an additional sixth substitution during extra-time will remain.
Dispensation will be given to all national team games until December 31st 2021.